2. Anti-infection
  3. Bacterial
  4. Streptokinase, β-hemolytic streptococcus (Lancefield Group C)

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) 

Cat. No.: HY-P2824
Data Sheet
SDS
COA
Handling Instructions Technical Support

Help & FAQs

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion.

For research use only. We do not sell to patients.

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) Chemical Structure

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) Chemical Structure

CAS No. : 9002-01-1

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  • Purity & Documentation

  • References

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Description

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2].

In Vitro

Product Information
Streptokinase is an extracellular metalloenzyme produced by beta-hemolytic streptococci and is used as an effective and inexpensive thrombolytic drug in certain cases of myocardial infarction (heart attack) and pulmonary embolism. It belongs to a group of drugs called fibrinolytics, which activate plasminogen by cleavage to produce plasmin.
Molecular Weight: ~47.3 kDa

Instructions
Reconstituted in purified water (1 mg/mL), or dissolved according to specific experimental references. After dissolution, store at 2-8°C and use within 1 week.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Sreptokinase (6000 IU/kg in 3 ml of saline; intracoronary; infused at 0.05 ml/min for 60 minutes beginning 30 minutes before reperfusion) maintains reperfusion coronary blood flow through a critical stenosis at a rate similar to baseline levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT00968929Beijing Chao Yang Hospital|Qingdao University|Tianjin Medical University General Hospital|General Hospital of Shenyang Military Region|Guangdong Institute of Respiratory Disease|The First Affiliated Hospital of Shanxi Medical University|Shenzhen People´s Hospital|Ningxia Medical University
Pulmonary Embolism|Pulmonary Thromboembolism
June 2006Phase 4
NCT03465085Beni-Suef University
Acute Respiratory Distress Syndrome|Severe Acute Respiratory Syndrome
February 18, 2016Phase 3
NCT02150785University of Alberta
Ischemic Stroke
June 2014Phase 2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Streptokinase, b-hemolytic streptococcus (Lancefield Group C)]
EC Number

3.4.99.0
Enzyme Activity

≥2000 U/mg soild
Unit Definition

One unit is equal to the amount of activity in one unit from a Streptoki nase International Standard reference vial.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Data Sheet (268 KB) SDS (251 KB)

COA (232 KB)

Handling Instructions (2659 KB)
References
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Streptokinase, β-hemolytic streptococcus (Lancefield Group C) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • How should lyophilized recombinant proteins be reconstituted and stored?

    1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.

  • How should solution-form recombinant proteins be stored?

    1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that

  • Why is it necessary to add carrier proteins?

    Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.

  • Carrier protein types and options?

    In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

Keywords:

Streptokinase, β-hemolytic streptococcus (Lancefield Group C)9002-01-1BacterialbacteriaproteinplasminogenactivatorbloodclottingdisordersInhibitorinhibitorinhibit

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