Stressin I TFA (Synonyms: Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA)

Cat. No.: HY-P1368A Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

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Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, K_i is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats.

For research use only. We do not sell to patients.

Stressin I TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 438	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 656	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Stressin I TFA:

Stressin I Get quote

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CRFR1 CRFR2

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

CRF1

Molecular Weight

4472.20 (free base)

Formula

C₂₀₃H₃₃₇N₅₇O₅₆.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-{d-Phe}-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Glu-His-Ser-Lys-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 (Covalent bond: Glu28-Lys31)

Sequence Shortening

Ac-PPISLDLT-{d-Phe}-HLLREVLE-{Nle}-ARAEQLAQQEHSKRKLXEII-NH2 (Covalent bond: Glu28-Lys31)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 1.98 mg/mL (ultrasonic and adjust pH to 3 with HCl)

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) RP-HPLC (110 KB) MS (221 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Rivier J, et al. Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J Med Chem. 2007 Apr 5;50(7):1668-74. [Content Brief] [Content Brief]

Stressin I TFA Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stressin ICyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)CRFRCorticotropin-releasing Factor ReceptorCRHRadrenal-intact male ratpellet outputInhibitorinhibitorinhibit

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