2. GPCR/G Protein
  3. CRFR
  4. Stressin I

Stressin I  (Synonyms: Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41))

Cat. No.: HY-P1368 Purity: 98.20%
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Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Stressin I Chemical Structure

Stressin I Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Stressin I:

Stressin I Related Antibodies

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Description

Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats[1].

IC50 & Target

Ki: 1.7 nM (CRF1), 222 nM (CRF2)[1]
Molecular Weight

4472.20

Formula

C203H337N57O56
Appearance

Solid

Color

White to off-white

Sequence

Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-{d-Phe}-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-{Nle}-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Glu-His-Ser-Lys-Arg-Lys-Leu-{Nle}-Glu-Ile-Ile-NH2 (Covalent bond: Glu28-Lys31)
Sequence Shortening

Ac-PPISLDLT-{d-Phe}-HLLREVLE-{Nle}-ARAEQLAQQEHSKRKL-{Nle}-EII-NH2 (Covalent bond: Glu28-Lys31)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (22.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2236 mL 1.1180 mL 2.2360 mL
5 mM 0.0447 mL 0.2236 mL 0.4472 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2236 mL 1.1180 mL 2.2360 mL 5.5901 mL
5 mM 0.0447 mL 0.2236 mL 0.4472 mL 1.1180 mL
10 mM 0.0224 mL 0.1118 mL 0.2236 mL 0.5590 mL
15 mM 0.0149 mL 0.0745 mL 0.1491 mL 0.3727 mL
20 mM 0.0112 mL 0.0559 mL 0.1118 mL 0.2795 mL
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Stressin I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stressin ICyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)CRFRCorticotropin-releasing Factor ReceptorCRHRadrenal-intact male ratpellet outputInhibitorinhibitorinhibit

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