2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. STX-721

STX-721 is a mutant-selective inhibitor of EGFR and HER2 Exon 20 insertion (ex20ins) mutants.

For research use only. We do not sell to patients.

STX-721 Chemical Structure

STX-721 Chemical Structure

Size Price Stock Quantity
1 mg USD 224 In-stock
5 mg USD 560 In-stock
10 mg USD 890 In-stock
25 mg USD 1875 In-stock
50 mg USD 3000 In-stock
100 mg USD 4800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

STX-721 Related Antibodies

Top Publications Citing Use of Products

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

STX-721 is a mutant-selective inhibitor of EGFR and HER2 Exon 20 insertion (ex20ins) mutants[1].

Molecular Weight

587.11

Formula

C32H35ClN6O3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCC[C@]1(C)C#CC2=C(C=CN=C2)C3=C(C4=C(N3)CCNC4=O)NC5=CC=CC(Cl)=C5OC)/C=C/CN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (170.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7033 mL 8.5163 mL 17.0326 mL
5 mM 0.3407 mL 1.7033 mL 3.4065 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7033 mL 8.5163 mL 17.0326 mL 42.5815 mL
5 mM 0.3407 mL 1.7033 mL 3.4065 mL 8.5163 mL
10 mM 0.1703 mL 0.8516 mL 1.7033 mL 4.2581 mL
15 mM 0.1136 mL 0.5678 mL 1.1355 mL 2.8388 mL
20 mM 0.0852 mL 0.4258 mL 0.8516 mL 2.1291 mL
25 mM 0.0681 mL 0.3407 mL 0.6813 mL 1.7033 mL
30 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4194 mL
40 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0645 mL
50 mM 0.0341 mL 0.1703 mL 0.3407 mL 0.8516 mL
60 mM 0.0284 mL 0.1419 mL 0.2839 mL 0.7097 mL
80 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
100 mM 0.0170 mL 0.0852 mL 0.1703 mL 0.4258 mL
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STX-721 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX-721STX721STX 721EGFREpidermal growth factor receptorErbB-1HER1EGFR InhibitorInhibitorinhibitorinhibit

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