Sublancin 

Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS). Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM^[1][2].

Sublancin (0-500 μM, 24 h) inhibits methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 15 μM, and exhibits no cytotoxicity in RAW246.7 macrophage cells, mouse peritoneal macrophages, and human Caco-2 253 epithelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sublancin (0.5-4 mg/kg, ip, single dose) ameliorates the MRSA infection in MRSA infected mice model through induction of IL-6 and MCP-1, attenuate the intestinal inflammation by inhibition of the NF-κB activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3878.38

C₁₆₂H₂₅₄N₅₀O₅₁S₅

207410-26-2

Gly-Leu-Gly-Lys-Ala-Gln-Cys-Ala-Ala-Leu-Trp-Leu-Gln-Cys-Ala-Ser-Gly-Gly-Thr-Ile-Gly-{Cys(D-glucopyranosyl)}-Gly-Gly-Gly-Ala-Val-Ala-Cys-Gln-Asn-Tyr-Arg-Gln-Phe-Cys-Arg (disulfide bridge: Cys7-Cys36, Cys14-Cys29)

GLGKAQCAALWLQCASGGTIG-{Cys(D-glucopyranosyl)}-GGGAVACQNYRQFCR (disulfide bridge: Cys7-Cys36, Cys14-Cys29)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang S, et al., Use of the Antimicrobial Peptide Sublancin with Combined Antibacterial and Immunomodulatory Activities To Protect against Methicillin-Resistant Staphylococcus aureus Infection in Mice. J Agric Food Chem. 2017 Oct 4;65(39):8595-8605.  [Content Brief]

  [2]. Wu C, et al., Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. 2019 Mar 8;5(3):454-459.  [Content Brief]