Substance P (5-11) (TFA)

Name: Substance P (5-11) (TFA)
Brand: MedChemExpress
SKU: HY-P3890A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3890A Purity: 97.16%: FAQs
Data Sheet SDS COA Handling Instructions

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Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Substance P (5-11) (TFA) Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Substance P (5-11) (TFA):

Substance P (5-11) Get quote

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NK1 NK2 NK3

Biological Activity
Purity & Documentation
References
Customer Review

Description

Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor^[1].

In Vitro

When a fraction from rabbit brain enriched in glial cells was incubated with [³H]Substance P (5-11) TFA TFA, an uptake of [3H]Substance P (5-11) TFA TFA is observed. When Substance P is released from nerve terminals, it is hydrolysed into Substance P (5-11) TFA TFA, which is in turn accumulated into glial cells as well as nerve terminals and that this high affinity uptake mechanism may play an important role in terminating the synaptic action of Substance P^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

869.04 (free base)

Formula

C₄₁H₆₀N₁₀O₉S.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Sequence Shortening

QQFFGLM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.16%

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Data Sheet (269 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (112 KB) MS (219 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. A Inoue, et al. Active uptake system for substance P carboxy-terminal heptapeptide (5-11) into a fraction from rabbit enriched in glial cells. Jpn J Pharmacol. 1984 Oct;36(2):137-45. [Content Brief]