2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Sulotroban

Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor). Sulotroban exhibits inhibitory activity against carbocyclic thromboxane A2- and endoperoxide-induced vasoconstrictor. Sulotroban inhibits platelets aggregation.

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Sulotroban Chemical Structure

Sulotroban Chemical Structure

CAS No. : 72131-33-0

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10 mg USD 500 In-stock
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Sulotroban Related Antibodies

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DP EP FP IP TXA2/TP TXB2

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Description

Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor). Sulotroban exhibits inhibitory activity against carbocyclic thromboxane A2- and endoperoxide-induced vasoconstrictor. Sulotroban inhibits platelets aggregation[1].

IC50 & Target

TXA2 Receptor

 

Molecular Weight

335.37

Formula

C16H17NO5S
CAS No.
Appearance

Solid

SMILES

O=C(COC1=CC=C(CCNS(=O)(C2=CC=CC=C2)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.09 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9818 mL 14.9089 mL 29.8178 mL
5 mM 0.5964 mL 2.9818 mL 5.9636 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9818 mL 14.9089 mL 29.8178 mL 74.5445 mL
5 mM 0.5964 mL 2.9818 mL 5.9636 mL 14.9089 mL
10 mM 0.2982 mL 1.4909 mL 2.9818 mL 7.4545 mL
15 mM 0.1988 mL 0.9939 mL 1.9879 mL 4.9696 mL
20 mM 0.1491 mL 0.7454 mL 1.4909 mL 3.7272 mL
25 mM 0.1193 mL 0.5964 mL 1.1927 mL 2.9818 mL
30 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8636 mL
50 mM 0.0596 mL 0.2982 mL 0.5964 mL 1.4909 mL
60 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
80 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9318 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL
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Sulotroban Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulotroban72131-33-0SKF-95587 BM-13177SKF95587SKF 95587BM13177BM 13177BM-13177Prostaglandin Receptorlupus nephritisangioplastyvascular smooth muscleplateletsrespiratory smooth muscleInhibitorinhibitorinhibit

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