2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Autophagy Apoptosis
  3. VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis
  4. Sunitinib-d10

Sunitinib-d10  (Synonyms: SU 11248-d10)

Cat. No.: HY-10255AS Purity: 99.89%
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Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

For research use only. We do not sell to patients.

Sunitinib-d<sub>10</sub> Chemical Structure

Sunitinib-d10 Chemical Structure

CAS No. : 1126721-82-1

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1 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sunitinib-d10:

Sunitinib-d10 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All PDGFR Isoform Specific Products:

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PDGFR PDGFRβ PDGFRα

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Description

Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

IC50 & Target[1]

VEGFR2

80 nM (IC50)

PDGFRβ

2 nM (IC50)

Molecular Weight

408.54

Formula

C22H17D10FN4O2
CAS No.
Unlabeled CAS

557795-19-4
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (50.99 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 20.83 mg/mL (50.99 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4477 mL 12.2387 mL 24.4774 mL
5 mM 0.4895 mL 2.4477 mL 4.8955 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.4477 mL 12.2387 mL 24.4774 mL 61.1935 mL
5 mM 0.4895 mL 2.4477 mL 4.8955 mL 12.2387 mL
10 mM 0.2448 mL 1.2239 mL 2.4477 mL 6.1194 mL
15 mM 0.1632 mL 0.8159 mL 1.6318 mL 4.0796 mL
20 mM 0.1224 mL 0.6119 mL 1.2239 mL 3.0597 mL
25 mM 0.0979 mL 0.4895 mL 0.9791 mL 2.4477 mL
30 mM 0.0816 mL 0.4080 mL 0.8159 mL 2.0398 mL
40 mM 0.0612 mL 0.3060 mL 0.6119 mL 1.5298 mL
50 mM 0.0490 mL 0.2448 mL 0.4895 mL 1.2239 mL
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Sunitinib-d10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sunitinib-d101126721-82-1SU 11248-d10VEGFRPDGFRIRE1MitophagyAutophagyApoptosisVascular endothelial growth factor receptorPlatelet-derived growth factor receptorInositol requiring enzyme 1Mitochondrial AutophagyDeuteriumlabeledIre1αautophosphorylationRNaseactivationInhibitorinhibitorinhibit

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