2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. SW02

SW02 is a potent activator of ATPase activity of Hsp70, with an EC50 of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau).

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SW02 Chemical Structure

SW02 Chemical Structure

CAS No. : 1010820-68-4

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Based on 1 publication(s) in Google Scholar

SW02 Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

SW02 is a potent activator of ATPase activity of Hsp70, with an EC50 of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau)[1].

IC50 & Target

TRAP1 ATPase

150 ± 21 μM (EC50)

Molecular Weight

439.30

Formula

C19H23BrN2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)CCCN1C(C)=C(C(OCC)=O)C(C2=CC=C(Br)C=C2)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (45.53 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2763 mL 11.3817 mL 22.7635 mL
5 mM 0.4553 mL 2.2763 mL 4.5527 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.30%

SDS (479 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2763 mL 11.3817 mL 22.7635 mL 56.9087 mL
5 mM 0.4553 mL 2.2763 mL 4.5527 mL 11.3817 mL
10 mM 0.2276 mL 1.1382 mL 2.2763 mL 5.6909 mL
15 mM 0.1518 mL 0.7588 mL 1.5176 mL 3.7939 mL
20 mM 0.1138 mL 0.5691 mL 1.1382 mL 2.8454 mL
25 mM 0.0911 mL 0.4553 mL 0.9105 mL 2.2763 mL
30 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8970 mL
40 mM 0.0569 mL 0.2845 mL 0.5691 mL 1.4227 mL
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SW02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW021010820-68-4SW 02SW-02HSPHeat shock proteinsdihydropyrimidineHeLa cellsATPaseHsp70Alzheimer's diseaseInhibitorinhibitorinhibit

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