T-1330

Cat. No.: HY-W111144: FAQs
Data Sheet Handling Instructions Technical Support

T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression.

For research use only. We do not sell to patients.

T-1330 Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Purity & Documentation
References
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Description

T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	GI₅₀	> 100 μM Compound: 45	Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay	[PMID: 27014922]

Molecular Weight

393.48

Formula

C₂₂H₂₇N₅O₂

CAS No.

106461-41-0

Appearance

Solid

SMILES

O=C1N(C2=CC=C(N3CCN(CC3)C4=CC=C(C=C4)O)C=C2)C=NN1C(CC)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Repurposing the Clinically Efficacious Jennifer R. Pace, et al. Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J. Med. Chem. 2016, 59, 8, 3635–3649.

T-1330 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-1330106461-41-0T1330T 1330HedgehogInhibitorinhibitorinhibit

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