2. Cell Cycle/DNA Damage
  3. Topoisomerase DNA/RNA Synthesis
  4. T-2513 hydrochloride

T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.

For research use only. We do not sell to patients.

T-2513 hydrochloride Chemical Structure

T-2513 hydrochloride Chemical Structure

CAS No. : 187793-52-8

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T-2513 hydrochloride Related Antibodies

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Description

T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

SN-38 is the metabolite of T-2513 hydrochloride[1].
T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T-2513 hydrochloride Related Antibodies

Cell Viability Assay[2]

Cell Line: WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells
Concentration: 15.1-111.5 ng/mL
Incubation Time: 24 hours
Result: Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively.
In Vivo

T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats bearing Walker-256 carcinoma[2]
Dosage: 1, 10, and 100 mg/kg
Administration:
Result: The ED50 was 23 mg/kg.
Molecular Weight

485.96

Formula

C25H28ClN3O5
CAS No.
SMILES

CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(OCCCN)C=C51.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T-2513 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-2513187793-52-8T2513T 2513TopoisomeraseDNA/RNA SynthesistopoisomeraseDNAreplicationRNAsynthesisT-0128SN-38Inhibitorinhibitorinhibit

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