2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. T2AA

T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase.

For research use only. We do not sell to patients.

T2AA Chemical Structure

T2AA Chemical Structure

CAS No. : 1380782-27-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 124 In-stock
Solution
10 mM * 1 mL in DMSO USD 124 In-stock
Solid
1 mg USD 30 In-stock
5 mg USD 110 In-stock
10 mg USD 175 In-stock
25 mg USD 370 In-stock
50 mg USD 590 In-stock
100 mg USD 940 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

T2AA Related Antibodies

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Description

T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].

In Vitro

T2AA (15 μM, 72 h) inhibits interstrand DNA crosslink (ICL) repair, it can prevent the disassembly of DNA double-strand break (DSB) formed as an ICL repair intermediate, and has the ability to inhibit DSB repair[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T2AA Related Antibodies
Molecular Weight

511.09

Formula

C15H15I2NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC(C=C(C[C@H](N)CO)C=C1I)=C1OC2=CC=C(O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9566 mL 9.7830 mL 19.5660 mL
5 mM 0.3913 mL 1.9566 mL 3.9132 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9566 mL 9.7830 mL 19.5660 mL 48.9151 mL
5 mM 0.3913 mL 1.9566 mL 3.9132 mL 9.7830 mL
10 mM 0.1957 mL 0.9783 mL 1.9566 mL 4.8915 mL
15 mM 0.1304 mL 0.6522 mL 1.3044 mL 3.2610 mL
20 mM 0.0978 mL 0.4892 mL 0.9783 mL 2.4458 mL
25 mM 0.0783 mL 0.3913 mL 0.7826 mL 1.9566 mL
30 mM 0.0652 mL 0.3261 mL 0.6522 mL 1.6305 mL
40 mM 0.0489 mL 0.2446 mL 0.4892 mL 1.2229 mL
50 mM 0.0391 mL 0.1957 mL 0.3913 mL 0.9783 mL
60 mM 0.0326 mL 0.1631 mL 0.3261 mL 0.8153 mL
80 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6114 mL
100 mM 0.0196 mL 0.0978 mL 0.1957 mL 0.4892 mL
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T2AA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T2AA1380782-27-3DNA/RNA SynthesisDNA repairdouble-strand breaknecroptosisG1 phaseInhibitorinhibitorinhibit

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