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Tadocizumab  (Synonyms: C4G1; YM-337)

Cat. No.: HY-P99560
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Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3.

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CAS No. : 339086-80-5

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Based on 1 publication(s) in Google Scholar

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research[1][2]. In Vitro:Tadocizumab (YM-337) significantly inhibits ex vivo ADP-induced platelet aggregation, and completely inhibits arachidonic acid-induced platelet aggregation[1].
Tadocizumab (YM-337) inhibits human platelet adhesion to von Willebrand factor, fibrinogen, fibronectin and subendothelial matrix[2]. In Vivo:Tadocizumab (YM-337; C4G1) dose-dependently inhibits ex vivo platelet aggregation, with complete inhibition at doses higher than 0.25 mg/kg intravenous injection or 1.5 μg/kg/min infusion in rhesus monkeys[1].
Tadocizumab (YM-337; C4G1) at a dose of 1 mg/kg intravenous injection followed by 6 μg/kg/min infusion for 60 min prevented occlusive thrombus formation in monkeys, in a photochemically-induced thrombosis model in squirrel monkeys[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target[1]

GPIIb/IIIa

 

CAS No.
SMILES

[Tadocizumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Fab-G1-kappa
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Tadocizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tadocizumab339086-80-5C4G1 YM-337YM337YM 337YM-337Integrincardiovascular systemintegrin αIIbβ3antiplatelet and antithrombotic effectsplatelet aggregationInhibitorinhibitorinhibit

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