2. GPCR/G Protein
  3. Kisspeptin Receptor
  4. TAK-448

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TAK-448 Chemical Structure

TAK-448 Chemical Structure

CAS No. : 1234319-68-6

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAK-448:

TAK-448 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TAK-448

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].

IC50 & Target

IC50: 460 pM (KISS1R)[1]
EC50: 632 pM (KISS1R)[1]
In Vivo

TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)
Dosage: 0.01, 0.03, 0.3, 3 mg/kg
Administration: Given i.h.; dosings on day 0 and 28
Result: Had greater anti-tumor effects in VCaP xenograft model.
Clinical Trial
Molecular Weight

1225.36

Formula

C58H80N16O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (81.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8161 mL 4.0804 mL 8.1609 mL
5 mM 0.1632 mL 0.8161 mL 1.6322 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8161 mL 4.0804 mL 8.1609 mL 20.4022 mL
5 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0804 mL
10 mM 0.0816 mL 0.4080 mL 0.8161 mL 2.0402 mL
15 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3601 mL
20 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0201 mL
25 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8161 mL
30 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6801 mL
40 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL
50 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4080 mL
60 mM 0.0136 mL 0.0680 mL 0.1360 mL 0.3400 mL
80 mM 0.0102 mL 0.0510 mL 0.1020 mL 0.2550 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TAK-448 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-4481234319-68-6MVT-602TAK448TAK 448MVT602MVT 602Kisspeptin ReceptorKiss1RGPR54Inhibitorinhibitorinhibit

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