Tamsulosin-d₄  (Synonyms: (R)-(-)-YM12617 (free base)-d₄; LY253351 (free base)-d₄)

Tamsulosin-d₄ ((R)-(-)-YM12617 (free base)-d₄) is deuterium labeled Tamsulosin. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α₁-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models^[1][2].

412.54

C₂₀H₂₄D₄N₂O₅S

1231943-97-7

106133-20-4

NS(=O)(C1=C(C=CC(C[C@@H](C)NC([2H])([2H])C([2H])([2H])OC2=C(C=CC=C2)OCC)=C1)OC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Christopher Chapple, et al. Tamsulosin: an overview. World J Urol. 2002 Apr;19(6):397-404.  [Content Brief]

  [3]. William G. Montgomery, BA, et al. Tamsulosin Attenuates Abdominal Aortic Aneurysm Growth. Surgery. 2018 Nov; 164(5): 1087–1092.  [Content Brief]