2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Tazarotenic acid

Tazarotenic acid  (Synonyms: AGN 190299)

Cat. No.: HY-101108 Purity: 99.57%
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Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.

For research use only. We do not sell to patients.

Tazarotenic acid Chemical Structure

Tazarotenic acid Chemical Structure

CAS No. : 118292-41-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 116 In-stock
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10 mM * 1 mL in DMSO USD 116 In-stock
Solid
5 mg USD 106 In-stock
10 mg USD 176 In-stock
25 mg USD 371 In-stock
50 mg USD 593 In-stock
100 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tazarotenic acid:

Tazarotenic acid Related Antibodies

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Description

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].

In Vivo

Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1]
.

Male Female Male
Dose (mg kg-1) 4.4 4.4 0.49
AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95)
CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2)
k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115)
T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16)
V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15)
Vβ (L kg-1) - - 1.14 (0.09)
Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) -
Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

323.41

Formula

C19H17NO2S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC=C(C#CC2=CC=C3C(C(C)(C)CCS3)=C2)N=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (309.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0921 mL 15.4603 mL 30.9205 mL
5 mM 0.6184 mL 3.0921 mL 6.1841 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0921 mL 15.4603 mL 30.9205 mL 77.3013 mL
5 mM 0.6184 mL 3.0921 mL 6.1841 mL 15.4603 mL
10 mM 0.3092 mL 1.5460 mL 3.0921 mL 7.7301 mL
15 mM 0.2061 mL 1.0307 mL 2.0614 mL 5.1534 mL
20 mM 0.1546 mL 0.7730 mL 1.5460 mL 3.8651 mL
25 mM 0.1237 mL 0.6184 mL 1.2368 mL 3.0921 mL
30 mM 0.1031 mL 0.5153 mL 1.0307 mL 2.5767 mL
40 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9325 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.5460 mL
60 mM 0.0515 mL 0.2577 mL 0.5153 mL 1.2884 mL
80 mM 0.0387 mL 0.1933 mL 0.3865 mL 0.9663 mL
100 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7730 mL
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Tazarotenic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tazarotenic acid118292-41-4AGN 190299AGN190299AGN-190299Drug MetaboliteTazaroteneretinoic acid receptorretinoid actionwarty dyskeratomaInhibitorinhibitorinhibit

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