2. Epigenetics PROTAC
  3. Histone Methyltransferase Target Protein Ligand-Linker Conjugates
  4. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH 

Cat. No.: HY-147090 Purity: 98.24%
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Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma.

For research use only. We do not sell to patients.

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Chemical Structure

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Chemical Structure

CAS No. : 2750350-39-9

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5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
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Based on 1 publication(s) in Google Scholar

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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  • Purity & Documentation

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  • Customer Review

Description

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma[1].

IC50 & Target[1]

EZH2

 

Molecular Weight

605.72

Formula

C34H43N3O7
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C(COCCCOC1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 160 mg/mL (264.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6509 mL 8.2546 mL 16.5093 mL
5 mM 0.3302 mL 1.6509 mL 3.3019 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

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Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6509 mL 8.2546 mL 16.5093 mL 41.2732 mL
5 mM 0.3302 mL 1.6509 mL 3.3019 mL 8.2546 mL
10 mM 0.1651 mL 0.8255 mL 1.6509 mL 4.1273 mL
15 mM 0.1101 mL 0.5503 mL 1.1006 mL 2.7515 mL
20 mM 0.0825 mL 0.4127 mL 0.8255 mL 2.0637 mL
25 mM 0.0660 mL 0.3302 mL 0.6604 mL 1.6509 mL
30 mM 0.0550 mL 0.2752 mL 0.5503 mL 1.3758 mL
40 mM 0.0413 mL 0.2064 mL 0.4127 mL 1.0318 mL
50 mM 0.0330 mL 0.1651 mL 0.3302 mL 0.8255 mL
60 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.6879 mL
80 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5159 mL
100 mM 0.0165 mL 0.0825 mL 0.1651 mL 0.4127 mL
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Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH2750350-39-9Histone MethyltransferaseTarget Protein Ligand-Linker ConjugatesLymphomaInhibitorinhibitorinhibit

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