TB-11

Cat. No.: HY-164958: FAQs
Data Sheet Handling Instructions

Molarity Calculator

TB-11 is a Cathepsin D inhibitor, with IC₅₀s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research.

For research use only. We do not sell to patients.

TB-11 Chemical Structure

CAS No. : 1415033-93-0

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

View All Beta-secretase Isoform Specific Products:

View All Isoforms

BACE1 BACE2

Biological Activity
Purity & Documentation
References
Customer Review

Description

TB-11 is a Cathepsin D inhibitor, with IC₅₀s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research^[1].

IC₅₀ & Target^[1]

Cathepsin D

0.126 nM (IC₅₀)

Cathepsin E

1.92 nM (IC₅₀)

BACE1

48.8 nM (IC₅₀)

Molecular Weight

1007.22

Formula

C₅₂H₇₈N₈O₁₂

CAS No.

1415033-93-0

SMILES

CC(C)(C)OC(N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(OC)=O)=O)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25(4):e3154. [Content Brief]

TB-11 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TB-111415033-93-0TB11TB 11CathepsinBeta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks