1. Stem Cell/Wnt Apoptosis Metabolic Enzyme/Protease
  2. β-catenin Apoptosis Caspase MDM-2/p53 Bcl-2 Family Cytochrome P450
  3. TCF4/β-catenin-IN-1

TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells.

For research use only. We do not sell to patients.

TCF4/β-catenin-IN-1 Chemical Structure

TCF4/β-catenin-IN-1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells[1].

In Vitro

TCF4/β-catenin-IN-1 (0.4-100 μM, 24 h) exhibits cytotoxic activity against the HCT-116, A549 and HepG2 cancer cell lines, with IC50 values of 8.52 μM, 5.87 μM and 3.12 μM, respectively[1].
TCF4/β-catenin-IN-1 (8.52 μM, 24 h) can significantly increases p53 and pro-apoptotic Bax expression levels, and down regulates the anti-apoptotic Bcl-2 expression levels in HCT-116 cell line[1].
TCF4/β-catenin-IN-1 (5-20 μM) suppressesβ-catenin and TCF-4 expression in HCT-116 cells in a dose-dependent manner[1].
TCF4/β-catenin-IN-1 (8.52 μM) can significantly increase caspase-3, caspase-8 and caspase-9 expression levels in HCT-116 cell line[1].
TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCT-116, A549, HepG2
Concentration: 0.4-100 μM
Incubation Time: 24 h
Result: Exhibited cytotoxic activity against the HCT-116, A549 and HepG2 cancer cell lines, where the IC50 values were 8.52 μM, 5.87 μM and 3.12 μM, respectively.
Molecular Weight

437.41

Formula

C23H15N7O3

SMILES

N#CC1=C(C2=CC=C(OC)C(OC)=C2)N=C3NN=C4NC5=C(C=CC=C5)C4=C(C#N)N3C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TCF4/β-catenin-IN-1
Cat. No.:
HY-172393
Quantity:
MCE Japan Authorized Agent: