2. Anti-infection
  3. Parasite
  4. TCMDC-135051 hydrochloride

TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM).

For research use only. We do not sell to patients.

TCMDC-135051 hydrochloride Chemical Structure

TCMDC-135051 hydrochloride Chemical Structure

CAS No. : 2705545-47-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 447 In-stock
Solution
10 mM * 1 mL in DMSO USD 447 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
50 mg USD 1900 In-stock
100 mg USD 2800 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TCMDC-135051 hydrochloride:

TCMDC-135051 hydrochloride Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM)[1].

In Vitro

TCMDC-135051 hydrochloride shows potent activity against P. berghei sporozoites in a liver invasion and development assay in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 hydrochloride has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCMDC-135051 hydrochloride Related Antibodies
Molecular Weight

508.05

Formula

C29H34ClN3O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(C2=C3C(NC(C4=C(OC)C=CC(CN(CC)CC)=C4)=C3)=NC=C2)C=C1C(C)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (164.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9683 mL 9.8416 mL 19.6831 mL
5 mM 0.3937 mL 1.9683 mL 3.9366 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9683 mL 9.8416 mL 19.6831 mL 49.2078 mL
5 mM 0.3937 mL 1.9683 mL 3.9366 mL 9.8416 mL
10 mM 0.1968 mL 0.9842 mL 1.9683 mL 4.9208 mL
15 mM 0.1312 mL 0.6561 mL 1.3122 mL 3.2805 mL
20 mM 0.0984 mL 0.4921 mL 0.9842 mL 2.4604 mL
25 mM 0.0787 mL 0.3937 mL 0.7873 mL 1.9683 mL
30 mM 0.0656 mL 0.3281 mL 0.6561 mL 1.6403 mL
40 mM 0.0492 mL 0.2460 mL 0.4921 mL 1.2302 mL
50 mM 0.0394 mL 0.1968 mL 0.3937 mL 0.9842 mL
60 mM 0.0328 mL 0.1640 mL 0.3281 mL 0.8201 mL
80 mM 0.0246 mL 0.1230 mL 0.2460 mL 0.6151 mL
100 mM 0.0197 mL 0.0984 mL 0.1968 mL 0.4921 mL
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TCMDC-135051 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCMDC-1350512705545-47-5TCMDC135051TCMDC 135051ParasiteplasmodiumfalciparumproteinkinasemalariaselectiveparasitemutationtranscriptionInhibitorinhibitorinhibit

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