2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. TDI-6570

TDI-6570  (Synonyms: TDI-006570)

Cat. No.: HY-164288 Purity: 99.64%
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TDI-6570 is a Cyclic GMP-AMP Synthase (cGAS) inhibitor with the IC50 of 0.138 μM.

For research use only. We do not sell to patients.

TDI-6570 Chemical Structure

TDI-6570 Chemical Structure

CAS No. : 2287331-29-5

Size Price Stock Quantity
1 mg USD 135 In-stock
5 mg USD 270 In-stock
10 mg USD 380 In-stock
25 mg USD 650 In-stock
50 mg USD 900 In-stock
100 mg USD 1220 In-stock
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TDI-6570 Related Antibodies

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Description

TDI-6570 is a Cyclic GMP-AMP Synthase (cGAS) inhibitor with the IC50 of 0.138 μM[1].

Molecular Weight

296.72

Formula

C14H14ClFN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CO)N1CC2=C(CC1)N(C)C3=C2C=CC(Cl)=C3F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (11.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3702 mL 16.8509 mL 33.7018 mL
5 mM 0.6740 mL 3.3702 mL 6.7404 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3702 mL 16.8509 mL 33.7018 mL 84.2545 mL
5 mM 0.6740 mL 3.3702 mL 6.7404 mL 16.8509 mL
10 mM 0.3370 mL 1.6851 mL 3.3702 mL 8.4255 mL
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TDI-6570 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDI-65702287331-29-5TDI-006570TDI6570TDI 6570TDI006570TDI 006570Cyclic GMP-AMP SynthasecGAScGAS-related autoimmune diseaseschronic inflammatorydiseasescancer metastasisInhibitorinhibitorinhibit

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