TDI-6570 (Synonyms: TDI-006570)

Cat. No.: HY-164288 Purity: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TDI-6570 is a Cyclic GMP-AMP Synthase (cGAS) inhibitor with the IC₅₀ of 0.138 μM.

For research use only. We do not sell to patients.

TDI-6570 Chemical Structure

CAS No. : 2287331-29-5

Size	Price	Stock	Quantity
5 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1220	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Purity & Documentation
References
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Description

TDI-6570 is a Cyclic GMP-AMP Synthase (cGAS) inhibitor with the IC₅₀ of 0.138 μM^[1].

Molecular Weight

296.72

Formula

C₁₄H₁₄ClFN₂O₂

CAS No.

2287331-29-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(CO)N1CC2=C(CC1)N(C)C3=C2C=CC(Cl)=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 3.33 mg/mL (11.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3702 mL	16.8509 mL	33.7018 mL
5 mM	0.6740 mL	3.3702 mL	6.7404 mL
10 mM	0.3370 mL	1.6851 mL	3.3702 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (259 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Daisuke Tomita, et al. Inhibitors of cgas for treating autoinflammatory diseases and cancer metastasis. WO2020186027A1. 2020-09-17.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3702 mL	16.8509 mL	33.7018 mL	84.2545 mL
	5 mM	0.6740 mL	3.3702 mL	6.7404 mL	16.8509 mL
	10 mM	0.3370 mL	1.6851 mL	3.3702 mL	8.4255 mL

TDI-6570 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDI-65702287331-29-5TDI-006570TDI6570TDI 6570TDI006570TDI 006570Cyclic GMP-AMP SynthasecGAScGAS-related autoimmune diseaseschronic inflammatorydiseasescancer metastasisInhibitorinhibitorinhibit

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