2. Cell Cycle/DNA Damage Autophagy Apoptosis
  3. DNA Alkylator/Crosslinker Autophagy Apoptosis
  4. Temozolomide-d3

Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

For research use only. We do not sell to patients.

Temozolomide-d<sub>3</sub> Chemical Structure

Temozolomide-d3 Chemical Structure

CAS No. : 208107-14-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Temozolomide-d3:

Temozolomide-d3 Related Antibodies

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Description

Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Temozolomide-d3 Related Antibodies
Molecular Weight

197.17

Formula

C6H3D3N6O2
CAS No.
Unlabeled CAS

85622-93-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1C=N2)N(N=NC1=C2C(N)=O)C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 5 mg/mL (25.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 5 mg/mL (25.36 mM)

DMF : ≥ 5 mg/mL (25.36 mM)

DMSO : ≥ 5 mg/mL (25.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

PBS (pH 7.2) : ≥ 0.33 mg/mL (1.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0718 mL 25.3588 mL 50.7177 mL
5 mM 1.0144 mL 5.0718 mL 10.1435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / DMSO / DMF / DMF / DMSO 1 mM 5.0718 mL 25.3588 mL 50.7177 mL 126.7941 mL
DMSO / DMF / DMF / DMSO 5 mM 1.0144 mL 5.0718 mL 10.1435 mL 25.3588 mL
10 mM 0.5072 mL 2.5359 mL 5.0718 mL 12.6794 mL
15 mM 0.3381 mL 1.6906 mL 3.3812 mL 8.4529 mL
20 mM 0.2536 mL 1.2679 mL 2.5359 mL 6.3397 mL
25 mM 0.2029 mL 1.0144 mL 2.0287 mL 5.0718 mL
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Temozolomide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Temozolomide-d3208107-14-6DNA Alkylator/CrosslinkerAutophagyApoptosisInhibitorinhibitorinhibit

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