Tetrazine-Amine monohydrochloride (Synonyms: (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride)

Name: Tetrazine-Amine monohydrochloride
Brand: MedChemExpress
SKU: HY-W053709A
Rating: 4.5 (1 reviews)

Cat. No.: HY-W053709A Purity: 98.29%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition. Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Tetrazine-Amine monohydrochloride Chemical Structure

CAS No. : 1416711-59-5

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Tetrazine-Amine monohydrochloride:

Tetrazine-Amine Get quote

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Description

Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition^[1]^[2]. Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

In Vitro

Click chemistry is used to describe the selective, modular, wide range and high-yield chemical reactions that allow rapid synthesis of new compounds through heteroatom linking (C-X-C). Bertozzi developed click chemistry in a new dimension —Bioorthogonal chemistry. It is defined as a rapid and selective reaction that does not interfere with biological processes under physiological conditions. Common reaction structures of click chemistry, such as Azide, Alkyne, DBCO, BCN, TCO and Tetrazine.?

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.67

Formula

C₉H₁₀ClN₅

CAS No.

1416711-59-5

Appearance

Solid

Color

Purple to purplish red

SMILES

NCC1=CC=C(C2=NN=CN=N2)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (447.09 mM)

DMSO : 62.5 mg/mL (279.43 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4709 mL	22.3547 mL	44.7093 mL
5 mM	0.8942 mL	4.4709 mL	8.9419 mL
10 mM	0.4471 mL	2.2355 mL	4.4709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.93%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (245 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Devaraj NK, et, al. Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition. Angew Chem Int Ed Engl. 2009;48(38):7013-6. [Content Brief]

[2]. Devaraj NK, et, al. Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem. 2008 Dec;19(12):2297-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.4709 mL	22.3547 mL	44.7093 mL	111.7733 mL
	5 mM	0.8942 mL	4.4709 mL	8.9419 mL	22.3547 mL
	10 mM	0.4471 mL	2.2355 mL	4.4709 mL	11.1773 mL
	15 mM	0.2981 mL	1.4903 mL	2.9806 mL	7.4516 mL
	20 mM	0.2235 mL	1.1177 mL	2.2355 mL	5.5887 mL
	25 mM	0.1788 mL	0.8942 mL	1.7884 mL	4.4709 mL
	30 mM	0.1490 mL	0.7452 mL	1.4903 mL	3.7258 mL
	40 mM	0.1118 mL	0.5589 mL	1.1177 mL	2.7943 mL
	50 mM	0.0894 mL	0.4471 mL	0.8942 mL	2.2355 mL
	60 mM	0.0745 mL	0.3726 mL	0.7452 mL	1.8629 mL
	80 mM	0.0559 mL	0.2794 mL	0.5589 mL	1.3972 mL
	100 mM	0.0447 mL	0.2235 mL	0.4471 mL	1.1177 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Tetrazine-Amine monohydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrazine-Amine monohydrochloride1416711-59-5(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochlorideTetrazine-NH2 monohydrochlorideBiochemical Assay ReagentsInhibitorinhibitorinhibit

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Tetrazine-Amine monohydrochloride (Synonyms: (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride)

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Tetrazine-Amine monohydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Tetrazine-Amine monohydrochloride Related Classifications

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