2. PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. GSK-3 Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species
  4. TFGF-18

TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment.

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TFGF-18 Chemical Structure

TFGF-18 Chemical Structure

CAS No. : 2222662-20-4

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TFGF-18 Related Antibodies

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Description

TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment[1][2].

Molecular Weight

613.53

Formula

C28H30F3NO11
CAS No.
SMILES

COC1=C(C(C=C(C2=CC(OC)=C(C=C2)OC)O3)=O)C3=CC(OC)=C1[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(N[C@@H](C)C(F)(F)F)=O
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TFGF-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TFGF-182222662-20-4TFGF18TFGF 18GSK-3ApoptosisCaspaseBcl-2 FamilyReactive Oxygen SpeciesGlycogen synthase kinase-3Glycogen synthase kinase 3NeuroinflammationmicrogliaInhibitorinhibitorinhibit

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