2. Apoptosis
  3. Transferrin Receptor
  4. TfR-T12 TFA

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TfR-T12 TFA Chemical Structure

TfR-T12 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 75 In-stock
5 mg USD 190 In-stock
10 mg USD 320 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of TfR-T12 TFA:

TfR-T12 TFA Related Antibodies

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Description

TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

In Vitro

TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TfR-T12 TFA Related Antibodies
Molecular Weight

1604.75

Formula

C73H100F3N19O17S
Appearance

Solid

Color

White to off-white

Sequence

Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro
Sequence Shortening

THRPPMWSPVWP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (62.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6231 mL 3.1158 mL 6.2315 mL
5 mM 0.1246 mL 0.6231 mL 1.2463 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6232 mL 3.1158 mL 6.2315 mL 15.5788 mL
5 mM 0.1246 mL 0.6232 mL 1.2463 mL 3.1158 mL
10 mM 0.0623 mL 0.3116 mL 0.6232 mL 1.5579 mL
15 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0386 mL
20 mM 0.0312 mL 0.1558 mL 0.3116 mL 0.7789 mL
25 mM 0.0249 mL 0.1246 mL 0.2493 mL 0.6232 mL
30 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5193 mL
40 mM 0.0156 mL 0.0779 mL 0.1558 mL 0.3895 mL
50 mM 0.0125 mL 0.0623 mL 0.1246 mL 0.3116 mL
60 mM 0.0104 mL 0.0519 mL 0.1039 mL 0.2596 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TfR-T12 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TfR-T12Transferrin ReceptorTfRCD71Inhibitorinhibitorinhibit

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