2. Apoptosis
  3. Transferrin Receptor
  4. TfR-T12

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TfR-T12 Chemical Structure

TfR-T12 Chemical Structure

CAS No. : 344618-30-0

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Based on 1 publication(s) in Google Scholar

Other Forms of TfR-T12:

TfR-T12 Related Antibodies

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Description

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

In Vitro

TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TfR-T12 Related Antibodies
Molecular Weight

1490.73

Formula

C71H99N19O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro
Sequence Shortening

THRPPMWSPVWP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (67.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6708 mL 3.3541 mL 6.7081 mL
5 mM 0.1342 mL 0.6708 mL 1.3416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6708 mL 3.3541 mL 6.7081 mL 16.7703 mL
5 mM 0.1342 mL 0.6708 mL 1.3416 mL 3.3541 mL
10 mM 0.0671 mL 0.3354 mL 0.6708 mL 1.6770 mL
15 mM 0.0447 mL 0.2236 mL 0.4472 mL 1.1180 mL
20 mM 0.0335 mL 0.1677 mL 0.3354 mL 0.8385 mL
25 mM 0.0268 mL 0.1342 mL 0.2683 mL 0.6708 mL
30 mM 0.0224 mL 0.1118 mL 0.2236 mL 0.5590 mL
40 mM 0.0168 mL 0.0839 mL 0.1677 mL 0.4193 mL
50 mM 0.0134 mL 0.0671 mL 0.1342 mL 0.3354 mL
60 mM 0.0112 mL 0.0559 mL 0.1118 mL 0.2795 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TfR-T12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TfR-T12344618-30-0Transferrin ReceptorTfRCD71Inhibitorinhibitorinhibit

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