TG-2-IN-4

Cat. No.: HY-160132 Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TG-2-IN-4 (compound 8) is a transglutaminase 2 (TG2) inhibitor with an IC₅₀ <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder.

For research use only. We do not sell to patients.

TG-2-IN-4 Chemical Structure

CAS No. : 2410899-01-1

Size	Price	Stock	Quantity
5 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 995	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2030	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

TG-2-IN-4 (compound 8) is a transglutaminase 2 (TG2) inhibitor with an IC₅₀ <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder^[1].

IC₅₀ & Target

IC50: <0.5 mM^[1]

Molecular Weight

612.72

Formula

C₃₄H₄₀N₆O₅

CAS No.

2410899-01-1

Appearance

Solid

Color

Off-white to yellow

SMILES

CC(C)CC1=C2C(N=C(N2)CN3C(C(NC([C@H](CC/C=C/C(N(C)C)=O)NC(OCC4=CC=CC=C4)=O)=O)=CC=C3)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (204.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6321 mL	8.1603 mL	16.3207 mL
5 mM	0.3264 mL	1.6321 mL	3.2641 mL
10 mM	0.1632 mL	0.8160 mL	1.6321 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (255 KB) HNMR (278 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Campbell D, et, al. Transglutaminase 2 (tg2) inhibitors. WO2020033784A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6321 mL	8.1603 mL	16.3207 mL	40.8017 mL
	5 mM	0.3264 mL	1.6321 mL	3.2641 mL	8.1603 mL
	10 mM	0.1632 mL	0.8160 mL	1.6321 mL	4.0802 mL
	15 mM	0.1088 mL	0.5440 mL	1.0880 mL	2.7201 mL
	20 mM	0.0816 mL	0.4080 mL	0.8160 mL	2.0401 mL
	25 mM	0.0653 mL	0.3264 mL	0.6528 mL	1.6321 mL
	30 mM	0.0544 mL	0.2720 mL	0.5440 mL	1.3601 mL
	40 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0200 mL
	50 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.8160 mL
	60 mM	0.0272 mL	0.1360 mL	0.2720 mL	0.6800 mL
	80 mM	0.0204 mL	0.1020 mL	0.2040 mL	0.5100 mL
	100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.4080 mL

TG-2-IN-4 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TG-2-IN-42410899-01-1Glutaminasetransglutaminase 2TG2inflammatoryInhibitorinhibitorinhibit

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