TG101209 analog 1

Cat. No.: HY-172089 Purity: 98.27%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

TG101209 analog 1 (Compound 8h) is an inhibitor for BUB1B with an IC₅₀ of 10.36 μM. TG101209 analog 1 exhibits cytotoxicity (IC₅₀ for Caki-1 is 1.347 μM), induce necrosis and apoptosis.

For research use only. We do not sell to patients.

TG101209 analog 1 Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

501.60

Formula

C₂₄H₃₁N₅O₅S

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC(NC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2C)=C1)(NC(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 350 mg/mL (697.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9936 mL	9.9681 mL	19.9362 mL
5 mM	0.3987 mL	1.9936 mL	3.9872 mL
10 mM	0.1994 mL	0.9968 mL	1.9936 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.27%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (247 KB) HNMR (266 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. El Hafi M, et al., Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma. Eur J Med Chem. 2025 Jan 9;285:117247. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9936 mL	9.9681 mL	19.9362 mL	49.8405 mL
	5 mM	0.3987 mL	1.9936 mL	3.9872 mL	9.9681 mL
	10 mM	0.1994 mL	0.9968 mL	1.9936 mL	4.9841 mL
	15 mM	0.1329 mL	0.6645 mL	1.3291 mL	3.3227 mL
	20 mM	0.0997 mL	0.4984 mL	0.9968 mL	2.4920 mL
	25 mM	0.0797 mL	0.3987 mL	0.7974 mL	1.9936 mL
	30 mM	0.0665 mL	0.3323 mL	0.6645 mL	1.6614 mL
	40 mM	0.0498 mL	0.2492 mL	0.4984 mL	1.2460 mL
	50 mM	0.0399 mL	0.1994 mL	0.3987 mL	0.9968 mL
	60 mM	0.0332 mL	0.1661 mL	0.3323 mL	0.8307 mL
	80 mM	0.0249 mL	0.1246 mL	0.2492 mL	0.6230 mL
	100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.4984 mL