2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-4-O-C13-NH2 hydrochloride

Thalidomide-4-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.

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Thalidomide-4-O-C13-NH2 hydrochloride Chemical Structure

Thalidomide-4-O-C13-NH2 hydrochloride Chemical Structure

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Thalidomide-4-O-C13-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide-4-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Molecular Weight

508.05

Formula

C26H38ClN3O5
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2C(NC(CC2)=O)=O)C(C(OCCCCCCCCCCCCCN)=CC=C3)=C3C1=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
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Thalidomide-4-O-C13-NH2 hydrochloride Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-4-O-C13-NH2Ligands for E3 LigaseE3 ligase-recruiting MoietyMolecular gelcereblon ligandPROTACCRBN proteintarget protein ligandconjugateInhibitorinhibitorinhibit

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