2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-5-PEG3-NH2 hydrochloride

Thalidomide-5-PEG3-NH2 hydrochloride 

Cat. No.: HY-138786A Purity: 97.93%
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Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-5-PEG3-NH2 hydrochloride Chemical Structure

Thalidomide-5-PEG3-NH2 hydrochloride Chemical Structure

CAS No. : 2761385-81-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-5-PEG3-NH2 hydrochloride:

Thalidomide-5-PEG3-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-5-PEG3-NH2 hydrochloride Related Antibodies
Molecular Weight

441.86

Formula

C19H24ClN3O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C(N1C2CCC(NC2=O)=O)C3=CC=C(OCCOCCOCCN)C=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Thalidomide-5-PEG3-NH2 hydrochloride Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5-PEG3-NH22761385-81-1E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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