2. PROTAC Autophagy
  3. Ligands for E3 Ligase Autophagy
  4. Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc

Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc 

Cat. No.: HY-161187
Handling Instructions

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Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

For research use only. We do not sell to patients.

Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc Chemical Structure

Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc Chemical Structure

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Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]
Molecular Weight

537.61

Formula

C28H35N5O6
SMILES

O=C1NC(CCC1N2C(C3=C(C=CC(N4CCC(CC4)N5C6(CC5)CN(C6)C(OC(C)(C)C)=O)=C3)C2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-boc Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-piperidine-1,6-diazaspiro[3.3]heptane-bocLigands for E3 LigaseAutophagyE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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