2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Thioproperazine

Thioproperazine  (Synonyms: RP 7843; SKF 5883; Thioperazine)

Cat. No.: HY-A0151 Purity: 99.90%
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Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder.

For research use only. We do not sell to patients.

Thioproperazine Chemical Structure

Thioproperazine Chemical Structure

CAS No. : 316-81-4

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thioproperazine:

Thioproperazine Related Antibodies

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  • Biological Activity

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Description

Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
4.32 μM
Compound: Thioproperazine
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
[PMID: 29624387]
In Vivo

Thioproperazine (5 mg/kg; i.p.; single) increases accumulation of dopamine in rat striatum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male charles river rats (200-250 g)[1].
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; single.
Result: Markedly decreased dopamine levels (26%), and accelerated synthesis and utilization of dopamine in the striatum (dopamine specific activity was enhanced 250%).
Molecular Weight

446.63

Formula

C22H30N4O2S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(N(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (27.99 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2390 mL 11.1949 mL 22.3899 mL
5 mM 0.4478 mL 2.2390 mL 4.4780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (393 KB)

COA (250 KB) HNMR (263 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2390 mL 11.1949 mL 22.3899 mL 55.9747 mL
5 mM 0.4478 mL 2.2390 mL 4.4780 mL 11.1949 mL
10 mM 0.2239 mL 1.1195 mL 2.2390 mL 5.5975 mL
15 mM 0.1493 mL 0.7463 mL 1.4927 mL 3.7316 mL
20 mM 0.1119 mL 0.5597 mL 1.1195 mL 2.7987 mL
25 mM 0.0896 mL 0.4478 mL 0.8956 mL 2.2390 mL
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Thioproperazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thioproperazine316-81-4RP 7843 SKF 5883 ThioperazineRP7843RP-7843SKF5883SKF 5883SKF-5883Dopamine Receptordopamineschizophreniabipolar disorderantiemeticstriatumInhibitorinhibitorinhibit

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