THR-β agonist 1

Name: THR-β agonist 1
Brand: MedChemExpress
SKU: HY-142441
Rating: 4.5 (1 reviews)

Cat. No.: HY-142441 Purity: 98.66%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

THR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2).

For research use only. We do not sell to patients.

THR-β agonist 1 Chemical Structure

CAS No. : 2648403-17-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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References
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Description

Molecular Weight

442.23

Formula

C₁₇H₁₄Cl₂FN₅O₄

CAS No.

2648403-17-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)N(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)N=C(CF)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2613 mL	11.3063 mL	22.6127 mL
5 mM	0.4523 mL	2.2613 mL	4.5225 mL
10 mM	0.2261 mL	1.1306 mL	2.2613 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (11.31 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (144 KB) RP-HPLC (163 KB) LCMS (234 KB)

Handling Instructions (2659 KB)

References

[1]. Hejun lv, et al. 1,2,4-triazine-3,5-dione compound and its preparation method and application. Patent WO2021104288A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2613 mL	11.3063 mL	22.6127 mL	56.5317 mL
	5 mM	0.4523 mL	2.2613 mL	4.5225 mL	11.3063 mL
	10 mM	0.2261 mL	1.1306 mL	2.2613 mL	5.6532 mL
	15 mM	0.1508 mL	0.7538 mL	1.5075 mL	3.7688 mL
	20 mM	0.1131 mL	0.5653 mL	1.1306 mL	2.8266 mL
	25 mM	0.0905 mL	0.4523 mL	0.9045 mL	2.2613 mL
	30 mM	0.0754 mL	0.3769 mL	0.7538 mL	1.8844 mL
	40 mM	0.0565 mL	0.2827 mL	0.5653 mL	1.4133 mL
	50 mM	0.0452 mL	0.2261 mL	0.4523 mL	1.1306 mL
	60 mM	0.0377 mL	0.1884 mL	0.3769 mL	0.9422 mL
	80 mM	0.0283 mL	0.1413 mL	0.2827 mL	0.7066 mL
	100 mM	0.0226 mL	0.1131 mL	0.2261 mL	0.5653 mL

THR-β agonist 1 Related Classifications

Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THR-β agonist 12648403-17-0Thyroid Hormone ReceptorTHRTHRβgrowthmetabolic balancethyroid hormonebodyphysiological activityInhibitorinhibitorinhibit

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THR-β agonist 1

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THR-β agonist 1 Related Antibodies

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

THR-β agonist 1 Related Classifications

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SAFETY DATA SHEET (SDS)

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