(Thr4,Gly7)-Oxytocin

Name: (Thr4,Gly7)-Oxytocin
Brand: MedChemExpress
SKU: HY-P3467
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3467 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

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(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K⁺ channels. .

For research use only. We do not sell to patients.

Custom Peptide Synthesis

(Thr4,Gly7)-Oxytocin Chemical Structure

CAS No. : 60786-59-6

Size	Price	Stock	Quantity
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

OT receptors, K⁺ channels^[1].

In Vitro

(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons^[1].
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons^[1].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells^[2].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice^[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss Webster mice ^[1]
Dosage:	1 μM
Administration:	Intratracheal administration for 24 h
Result:	Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.

Molecular Weight

940.10

Formula

C₃₉H₆₁N₁₁O₁₂S₂

CAS No.

60786-59-6

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (106.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (53.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0637 mL	5.3186 mL	10.6372 mL
5 mM	0.2127 mL	1.0637 mL	2.1274 mL
10 mM	0.1064 mL	0.5319 mL	1.0637 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (250 KB) RP-HPLC (111 KB) MS (224 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [Content Brief]

[2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. [Content Brief]

[3]. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.0637 mL	5.3186 mL	10.6372 mL	26.5929 mL
	5 mM	0.2127 mL	1.0637 mL	2.1274 mL	5.3186 mL
	10 mM	0.1064 mL	0.5319 mL	1.0637 mL	2.6593 mL
	15 mM	0.0709 mL	0.3546 mL	0.7091 mL	1.7729 mL
	20 mM	0.0532 mL	0.2659 mL	0.5319 mL	1.3296 mL
	25 mM	0.0425 mL	0.2127 mL	0.4255 mL	1.0637 mL
	30 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	40 mM	0.0266 mL	0.1330 mL	0.2659 mL	0.6648 mL
	50 mM	0.0213 mL	0.1064 mL	0.2127 mL	0.5319 mL
DMSO	60 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL
	80 mM	0.0133 mL	0.0665 mL	0.1330 mL	0.3324 mL
	100 mM	0.0106 mL	0.0532 mL	0.1064 mL	0.2659 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.