2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. THX-B

THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders.

For research use only. We do not sell to patients.

THX-B Chemical Structure

THX-B Chemical Structure

CAS No. : 1372206-64-8

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Customer Review

Based on 1 publication(s) in Google Scholar

THX-B Related Antibodies

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Description

THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders[1][2][3].

In Vitro

THX-B (10 μM, 4 days) decreases proliferation of myoblasts[1].
THX-B (10 μM, 1 h) inhibits NGF-induced phosphorylation of ERK1/2 in C2C12 myoblasts[1].
THX-B (20 μM, 24 h) decreases photoreceptor cell death and reactive gliosis in cultured rd10 retinas[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

THX-B Related Antibodies

Western Blot Analysis[1]

Cell Line: C2C12 myoblasts
Concentration: 10 μM
Incubation Time: Pre-treated for 1 hour
Result: Inhibited βNGF-induced ERK2 phosphorylation by 67%.
Inhibited proNGF-induced ERK2 phosphorylation by 90%.

Immunofluorescence[1]

Cell Line: Cultured P22 rd10 retinas.
Concentration: 20 μM
Incubation Time: 24 h
Result: Attenuated the thickening and enlargement of processes of astrocytes and Müller glia cells.
In Vivo

THX-B (50 μg in 125 μL PBS, i.p. weekly for 4 weeks) improves bladder function in a mouse model of diabetic voiding dysfunction[3].
THX-B (2 μL of 2 μg/μL, IVT injection, a single dose) elicits a neuroprotective effect on photoreceptor cells in P17 rd10 mice[2].
THX-B (40 μg in 20 μL, IVT injection) resolves the inflammatory, vascular, and neurodegenerative phases of the retinal pathology[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of diabetic voiding dysfunction
Dosage: 50 μg in 125 μL PBS
Administration: Intraperitoneal injection (i.p.)
Result: Prevented bladder weight increase, which was 18% (95% CI 3%, 32%) and 37% (95% CI 14%, 60%) lower after 2 and 4 weeks of treatment.
Animal Model: P17 rd10 mice[1]
Dosage: 2 μL of 2 μg/μL, single dose
Administration: Intravitreal (IVT) injected in one eye
Result: Increased the number of photoreceptor rows as well as the ONL/INL ratio.
Decreased the total number of microglial cells in the treated retinas, as well as some of the inflammatory signs, such as GFAP, α2M and the proinflammatory cytokines IL-1β and TNFα.
Molecular Weight

364.40

Formula

C16H24N6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C(C)C)C(NC(C)C)=O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (274.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7442 mL 13.7212 mL 27.4424 mL
5 mM 0.5488 mL 2.7442 mL 5.4885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7442 mL 13.7212 mL 27.4424 mL 68.6059 mL
5 mM 0.5488 mL 2.7442 mL 5.4885 mL 13.7212 mL
10 mM 0.2744 mL 1.3721 mL 2.7442 mL 6.8606 mL
15 mM 0.1829 mL 0.9147 mL 1.8295 mL 4.5737 mL
20 mM 0.1372 mL 0.6861 mL 1.3721 mL 3.4303 mL
25 mM 0.1098 mL 0.5488 mL 1.0977 mL 2.7442 mL
30 mM 0.0915 mL 0.4574 mL 0.9147 mL 2.2869 mL
40 mM 0.0686 mL 0.3430 mL 0.6861 mL 1.7151 mL
50 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3721 mL
60 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1434 mL
80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8576 mL
100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6861 mL
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THX-B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THX-B1372206-64-8Neurotensin Receptorp75NTRp75photoreceptorretinitispigmentosaP22βNGFERK2phosphorylationproNGFmyoblastretinadiabetesInhibitorinhibitorinhibit

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