2. Anti-infection Cell Cycle/DNA Damage Metabolic Enzyme/Protease Others
  3. Orthopoxvirus DNA/RNA Synthesis Endogenous Metabolite Isotope-Labeled Compounds
  4. Thymidine-13C5

Thymidine-13C5  (Synonyms: DThyd-13C5; NSC 21548-13C5)

Cat. No.: HY-W779017 Purity: 99.90%
COA Handling Instructions

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Thymidine-13C5 (DThyd-13C5; NSC 21548-13C5) is 13C-labeled Thymidine (HY-N1150).

For research use only. We do not sell to patients.

Thymidine-<sup>13</sup>C<sub>5</sub> Chemical Structure

Thymidine-13C5 Chemical Structure

CAS No. : 156968-81-9

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1 mg USD 270 In-stock
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
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Other Forms of Thymidine-13C5:

Thymidine-13C5 Related Antibodies

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Description

Thymidine-13C5 (DThyd-13C5; NSC 21548-13C5) is 13C-labeled Thymidine (HY-N1150)[1].

In Vitro

Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thymidine-13C5 Related Antibodies
In Vivo

Isotopic labels can non-invasively track the distribution, transformation and clearance of compounds and their metabolites in the body through techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), which is beneficial to the study of pharmacometabolic kinetics (ADME).
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

247.19

Formula

C513C5H14N2O5
CAS No.
Unlabeled CAS

50-89-5
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C=C(C(N1)=O)C)[13C@@H]2O[13C@@H]([13C@H]([13CH2]2)O)[13CH2]O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (202.27 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0455 mL 20.2274 mL 40.4547 mL
5 mM 0.8091 mL 4.0455 mL 8.0909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

COA (252 KB) HNMR (150 KB) CNMR (161 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0455 mL 20.2274 mL 40.4547 mL 101.1368 mL
5 mM 0.8091 mL 4.0455 mL 8.0909 mL 20.2274 mL
10 mM 0.4045 mL 2.0227 mL 4.0455 mL 10.1137 mL
15 mM 0.2697 mL 1.3485 mL 2.6970 mL 6.7425 mL
20 mM 0.2023 mL 1.0114 mL 2.0227 mL 5.0568 mL
25 mM 0.1618 mL 0.8091 mL 1.6182 mL 4.0455 mL
30 mM 0.1348 mL 0.6742 mL 1.3485 mL 3.3712 mL
40 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5284 mL
50 mM 0.0809 mL 0.4045 mL 0.8091 mL 2.0227 mL
60 mM 0.0674 mL 0.3371 mL 0.6742 mL 1.6856 mL
80 mM 0.0506 mL 0.2528 mL 0.5057 mL 1.2642 mL
100 mM 0.0405 mL 0.2023 mL 0.4045 mL 1.0114 mL
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Thymidine-13C5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thymidine-13C5156968-81-9DThyd-13C5 NSC 21548-13C5OrthopoxvirusDNA/RNA SynthesisEndogenous MetaboliteIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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