Thymine-d₄-1

Cat. No.: HY-W010450S4 Purity: 99.47%: FAQs
Data Sheet SDS COA Handling Instructions

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Thymine-d₄-1 is the deuterium labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].

For research use only. We do not sell to patients.

Thymine-d<sub>4</sub>-1 Chemical Structure

Thymine-d₄-1 Chemical Structure

CAS No. : 156054-85-2

Size	Price	Stock	Quantity
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Other Forms of Thymine-d₄-1:

Thymine In-stock

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

130.14

Formula

C₅H₂D₄N₂O₂

CAS No.

156054-85-2

Unlabeled CAS

65-71-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C([2H])([2H])[2H])=C([2H])NC(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (252 KB) HNMR (280 KB) RP-HPLC (663 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6. [Content Brief]

Thymine-d₄-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thymine-d₄-1156054-85-2Endogenous MetaboliteInhibitorinhibitorinhibit

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Thymine-d4-1

Other Forms of Thymine-d4-1:

Thymine-d4-1 Related Antibodies