Tilpisertib fosmecarbil TFA (Synonyms: GS 5290 TFA)

Cat. No.: HY-147404A Purity: 98.05%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tilpisertib fosmecarbil TFA is the TFA salt form of Tilpisertib (HY-147404). Tilpisertib fosmecarbil TFA is an inhibitor for serine/threonine kinase. Tilpisertib fosmecarbil TFA has anti-inflammatory activity.

For research use only. We do not sell to patients.

Tilpisertib fosmecarbil TFA Chemical Structure

CAS No. : 2567459-65-6

Size	Price	Stock	Quantity
1 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3680	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Tilpisertib fosmecarbil TFA:

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

861.16

Formula

C₃₇H₃₇ClF₃N₈O₉P

CAS No.

2567459-65-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=P(O)(O)OCOC(N(C1=CC2=C(N=CC(C#N)=C2NCC(C)(C)C)C(Cl)=C1)[C@@H](C3=C4C(C(N(C=C4)C)=O)=CC=C3)C5=CN(N=N5)C67CC(C7)C6)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (116.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1612 mL	5.8061 mL	11.6122 mL
5 mM	0.2322 mL	1.1612 mL	2.3224 mL
10 mM	0.1161 mL	0.5806 mL	1.1612 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.05%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (255 KB) HNMR (455 KB) CNMR (418 KB) RP-HPLC (109 KB)

Handling Instructions (2659 KB)

References

[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1612 mL	5.8061 mL	11.6122 mL	29.0306 mL
	5 mM	0.2322 mL	1.1612 mL	2.3224 mL	5.8061 mL
	10 mM	0.1161 mL	0.5806 mL	1.1612 mL	2.9031 mL
	15 mM	0.0774 mL	0.3871 mL	0.7741 mL	1.9354 mL
	20 mM	0.0581 mL	0.2903 mL	0.5806 mL	1.4515 mL
	25 mM	0.0464 mL	0.2322 mL	0.4645 mL	1.1612 mL
	30 mM	0.0387 mL	0.1935 mL	0.3871 mL	0.9677 mL
	40 mM	0.0290 mL	0.1452 mL	0.2903 mL	0.7258 mL
	50 mM	0.0232 mL	0.1161 mL	0.2322 mL	0.5806 mL
	60 mM	0.0194 mL	0.0968 mL	0.1935 mL	0.4838 mL
	80 mM	0.0145 mL	0.0726 mL	0.1452 mL	0.3629 mL
	100 mM	0.0116 mL	0.0581 mL	0.1161 mL	0.2903 mL

Tilpisertib fosmecarbil TFA Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilpisertib fosmecarbil2567459-65-6GS 5290GS5290GS-5290Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesInhibitorinhibitorinhibit

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