TLR7 agonist 29

Cat. No.: HY-173070: FAQs
Data Sheet Handling Instructions Technical Support

TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC₅₀ of 5.2 nM for human TLR7 (EC₅₀ for mouse TLR7 is 48.2 nM). TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC.

For research use only. We do not sell to patients.

TLR7 agonist 29 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

human TLR7

5.2 nM (EC₅₀)

mTLR7

48.2 nM (EC₅₀)

Molecular Weight

397.47

Formula

C₂₀H₂₇N₇O₂

SMILES

NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sega E, et al., Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells. Bioconjug Chem. 2025 Feb 13. [Content Brief]

TLR7 agonist 29 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 29Toll-like Receptor (TLR)IFNARPD-1/PD-L1ADC CytotoxinInterferon-α/β receptorInterferon-alpha/beta receptor PD-1/Programmed death-ligand 1ADC PayloadBMDMBALB/c mouseInhibitorinhibitorinhibit

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