2. MAPK/ERK Pathway
  3. MAP4K
  4. TNIK&MAP4K4-IN-1

TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition.

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TNIK&MAP4K4-IN-1 Chemical Structure

TNIK&MAP4K4-IN-1 Chemical Structure

CAS No. : 2478592-86-6

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TNIK&MAP4K4-IN-1 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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Description

TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition[1].

IC50 & Target

IC50: 1.29 nM (TNIK), <10 nM (MAP4K4/HGK)[1]
Molecular Weight

446.47

Formula

C25H23FN4O3
CAS No.
SMILES

O=C(C1=CC=C(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCC4)O1)NC5=C(OC)C=NC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNIK&MAP4K4-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK&MAP4K4-IN-12478592-86-6MAP4KMAPK Kinase Kinase KinaseantitumorTNIK kinas,e MAP4K4 inhibitorantifibroticfibrosiscancerInhibitorinhibitorinhibit

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