2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Topoisomerase Apoptosis
  4. Top/HDAC-IN-1

Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells.

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Top/HDAC-IN-1 Chemical Structure

Top/HDAC-IN-1 Chemical Structure

CAS No. : 2775446-49-4

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Top/HDAC-IN-1 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Topoisomerase Topo I Topo II

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Description

Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells[1].

Molecular Weight

509.56

Formula

C29H27N5O4
CAS No.
SMILES

CN1C2=C(C(N3CCC4=C(C13)NC5=C4C=C(C=C5)O)=O)C=C(C=C2)NCC6=CC=C(C=C6)/C=C/C(NO)=O
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Purity & Documentation
References
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Top/HDAC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Top/HDAC-IN-12775446-49-4HDACTopoisomeraseApoptosisHistone deacetylasesHistone deacetylaseAntitumor activityapoptosisHCT116Inhibitorinhibitorinhibit

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