2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 14

Topoisomerase I inhibitor 14 (Compound 4h) is an inhibitor for Topoisomerase I. Topoisomerase I inhibitor 14 inhibits proliferation of A549 and C6 with IC50s of 4.56 μM and 13.17 μM, without significant toxicity in healthy cells NIH3T3 (IC50 is 74.44 μM), which exhibits anticancer potency.

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Topoisomerase I inhibitor 14 Chemical Structure

Topoisomerase I inhibitor 14 Chemical Structure

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Topoisomerase I inhibitor 14 Related Antibodies

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Description

Topoisomerase I inhibitor 14 (Compound 4h) is an inhibitor for Topoisomerase I. Topoisomerase I inhibitor 14 inhibits proliferation of A549 and C6 with IC50s of 4.56 μM and 13.17 μM, without significant toxicity in healthy cells NIH3T3 (IC50 is 74.44 μM), which exhibits anticancer potency[1].

Molecular Weight

555.65

Formula

C28H29N9O2S
SMILES

COC1=CC=C(C2=NC3=CC=C(C4=NN=C(SCC(N5CCN(C6=NC=CC=N6)CC5)=O)N4CC)C=C3N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Topoisomerase I inhibitor 14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Topoisomerase I inhibitor 14Topoisomerase I inhibitor14Topoisomerase I inhibitor-14TopoisomeraseA549C6NIH3T3topoisomeraseInhibitorinhibitorinhibit

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