2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase I inhibitor 3

Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase.

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Topoisomerase I inhibitor 3 Chemical Structure

Topoisomerase I inhibitor 3 Chemical Structure

CAS No. : 2588211-50-9

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Topoisomerase I inhibitor 3 Related Antibodies

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Description

Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].

IC50 & Target

Topoisomerase I

 

In Vitro

Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC50 values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 3 Related Antibodies
Molecular Weight

311.31

Formula

C18H14FNO3
CAS No.
SMILES

COC1=C(C=C2N=C3COC4=C(C3=CC2=C1)C=C(F)C=C4)OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Topoisomerase I inhibitor 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 32588211-50-9Topoisomerase I inhibitor3Topoisomerase I inhibitor-3TopoisomeraseApoptosisHepG2anticancerInhibitorinhibitorinhibit

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