2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 6

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases.

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Topoisomerase I inhibitor 6 Chemical Structure

Topoisomerase I inhibitor 6 Chemical Structure

CAS No. : 2393082-56-7

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Topoisomerase I inhibitor 6 Related Antibodies

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Description

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 10 μM
Compound: 3
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
MCF7 IC50
2.5 μM
Compound: 3
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
Molecular Weight

411.46

Formula

C23H21N7O
CAS No.
SMILES

NC1=CC=C(C=C1)C2=CC=C3N=CC(C4=NN=CO4)=C(C3=C2)NCCCN5C=CN=C5
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Topoisomerase I inhibitor 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 62393082-56-7Topoisomerase I inhibitor6Topoisomerase I inhibitor-6TopoisomeraseTopoisomerase IDNA-Top1cytotoxiccancerInhibitorinhibitorinhibit

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