2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Topoisomerase EGFR
  4. Topoisomerase II/EGFR-IN-1

Topoisomerase II/EGFR-IN-1 is topoisomerase II/EGFR dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer.

For research use only. We do not sell to patients.

Topoisomerase II/EGFR-IN-1 Chemical Structure

Topoisomerase II/EGFR-IN-1 Chemical Structure

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Topoisomerase II/EGFR-IN-1 Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

View All EGFR Isoform Specific Products:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

Topoisomerase II/EGFR-IN-1 is topoisomerase II/EGFR dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer[1].

IC50 & Target

Topoisomerase II

 

Molecular Weight

428.38

Formula

C21H8N4O5S
SMILES

O=C(C1=C(C2=O)C=CC=C1)C3=C2SC4=NC(C(C=C5)=CC=C5[N+]([O-])=O)=C(C#N)C(N43)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase II/EGFR-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II/EGFR-IN-1TopoisomeraseEGFREpidermal growth factor receptorErbB-1HER1MCF-7A549HCT-116anticancerInhibitorinhibitorinhibit

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