2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase II inhibitor 11

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity.

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Topoisomerase II inhibitor 11 Chemical Structure

Topoisomerase II inhibitor 11 Chemical Structure

CAS No. : 2476559-00-7

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Topoisomerase II inhibitor 11 Related Antibodies

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Description

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].

IC50 & Target

Topoisomerase II

2.89 μM (IC50)

Molecular Weight

588.34

Formula

C27H21BrCl2N2O2S
CAS No.
SMILES

O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Topoisomerase II inhibitor 11 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 112476559-00-7Topoisomerase II inhibitor11Topoisomerase II inhibitor-11TopoisomeraseApoptosisrenal cancerA498Triazolopyrimidinestopoisomerase IIflow cytometryapoptosisInhibitorinhibitorinhibit

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