2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 12

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity.

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Topoisomerase II inhibitor 12 Chemical Structure

Topoisomerase II inhibitor 12 Chemical Structure

CAS No. : 2304527-20-4

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Topoisomerase II inhibitor 12 Related Antibodies

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Description

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].

In Vitro

Topoisomerase II inhibitor 12 (Compound 8c) shows anti-proliferative activities with IC50 values of 8.80 ± 0.12, 7.13 ± 0.20, 6.56 ± 0.15, 10.99 ± 0.23, 10.71 ± 0.03 and 13.27 ± 0.32 μM against HepG2, HCT116, MDA-MB-231, Hela, K562 and PDLSC cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 12 Related Antibodies
Molecular Weight

649.95

Formula

C40H63N3O4
CAS No.
SMILES

CCCCCCCCCCCCOC1=C(C(C2=C(C3=O)C=CC=C2)=O)C3=C(C=C1)OCCCCNCCCNCCCCNCCC
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Purity & Documentation
References
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Topoisomerase II inhibitor 12 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 122304527-20-4Topoisomerase II inhibitor12Topoisomerase II inhibitor-12TopoisomeraseHepG2HCT116MDA-MB-231HelaK562PDLSCantineoplasticInhibitorinhibitorinhibit

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