2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 18

Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer.

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Topoisomerase II inhibitor 18 Chemical Structure

Topoisomerase II inhibitor 18 Chemical Structure

CAS No. : 2382959-65-9

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Topoisomerase II inhibitor 18 Related Antibodies

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Description

Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer[1].

IC50 & Target

Topoisomerase II

7.5 μM (IC50)

In Vitro

Topoisomerase II inhibitor 18 (0-100 μM) inhibits proliferations of cancer cells PC-3 and HepG2 with IC50s of 2.11 and 11.03 μM, without significant cytotoxicity in normal cells Vero (IC50 is 23.12 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 18 Related Antibodies

Western Blot Analysis[1]

Cell Line: PC-3
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Increased levels of p53, cleaved caspase-3 and cleaved caspase-8.
Decreased levels of Bcl-2.

Cell Proliferation Assay[1]

Cell Line: HepG2, PC-3
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Inhibited proliferations of PC-3 and HepG2
In Vivo

Topoisomerase II inhibitor 18 (5 mg/kg, i.m. for 21 days) exhibits antitumor activity in Ehrlich solid tumor bearing albino mice, exhibits kidney protective efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ehrlich solid tumor bearing albino mice[1]
Dosage: 5 mg/kg
Administration: i.m. for 21 days
Result: Inhibited tumor growth.
Molecular Weight

351.47

Formula

C20H21N3OS
CAS No.
SMILES

O=C(NCCC)CCSC1=NC2=CC=CC=C2N=C1C3=CC=CC=C3
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Purity & Documentation
References
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Topoisomerase II inhibitor 18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 182382959-65-9Topoisomerase II inhibitor18Topoisomerase II inhibitor-18TopoisomeraseHepG2PC-3Veroprostate cancerliver cancerSECInhibitorinhibitorinhibit

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