2. Cell Cycle/DNA Damage Apoptosis Autophagy
  3. Topoisomerase Apoptosis Autophagy
  4. Topotecan hydrochloride hydrate

Topotecan hydrochloride hydrate  (Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

Cat. No.: HY-13768C
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Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity.

For research use only. We do not sell to patients.

Topotecan hydrochloride hydrate Chemical Structure

Topotecan hydrochloride hydrate Chemical Structure

CAS No. : 1044663-62-8

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Topotecan hydrochloride hydrate Related Antibodies

Top Publications Citing Use of Products

    Topotecan hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.  [Abstract]

    WDR5 inhibitor OICR-9429 enhances the sensitivity of ovarian cancer to genotoxic chemotherapeutics in vivo. Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.

    Topotecan hydrochloride hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.  [Abstract]

    IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.

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    Topoisomerase Topo I Topo II

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    Description

    Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

    IC50 & Target

    Topoisomerase I

     

    In Vitro

    Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1].
    Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].
    Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Topotecan hydrochloride hydrate Related Antibodies
    In Vivo

    Topotecan hydrochloride hydrate (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    475.92

    Formula

    C23H26ClN3O6
    CAS No.
    SMILES

    O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.Cl.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Topotecan hydrochloride hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Topotecan hydrochloride1044663-62-8SKF 104864A hydrochlorideNSC 609669 hydrochlorideTopoisomeraseApoptosisAutophagyU251U87GSCs-U251GSCs-U87orally activeInhibitorinhibitorinhibit

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