2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. TPI-287

TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain.

For research use only. We do not sell to patients.

TPI-287 Chemical Structure

TPI-287 Chemical Structure

CAS No. : 849213-15-6

Size Price Stock Quantity
1 mg USD 751 In-stock
5 mg USD 1727 In-stock
10 mg USD 2764 In-stock
25 mg USD 5528 In-stock
50 mg USD 8846 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

TPI-287 Related Antibodies

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Description

TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1].

In Vivo

TPI-287(i.v., 18 mg/kg, every 4 days, 41 days) can effectively reduce tumor volume and inhibit tumor growth in mouse tumor models inoculated with 231-BR breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

869.99

Formula

C46H63NO15
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1(C)[C@@]2(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC(C)C)=O)C(C)=C1[C@]([H])(OC(C)=O)[C@@]3([H])[C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@]4([H])OC(C=C)O3)([H])[C@@H]2OC(C6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (114.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1494 mL 5.7472 mL 11.4944 mL
5 mM 0.2299 mL 1.1494 mL 2.2989 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1494 mL 5.7472 mL 11.4944 mL 28.7360 mL
5 mM 0.2299 mL 1.1494 mL 2.2989 mL 5.7472 mL
10 mM 0.1149 mL 0.5747 mL 1.1494 mL 2.8736 mL
15 mM 0.0766 mL 0.3831 mL 0.7663 mL 1.9157 mL
20 mM 0.0575 mL 0.2874 mL 0.5747 mL 1.4368 mL
25 mM 0.0460 mL 0.2299 mL 0.4598 mL 1.1494 mL
30 mM 0.0383 mL 0.1916 mL 0.3831 mL 0.9579 mL
40 mM 0.0287 mL 0.1437 mL 0.2874 mL 0.7184 mL
50 mM 0.0230 mL 0.1149 mL 0.2299 mL 0.5747 mL
60 mM 0.0192 mL 0.0958 mL 0.1916 mL 0.4789 mL
80 mM 0.0144 mL 0.0718 mL 0.1437 mL 0.3592 mL
100 mM 0.0115 mL 0.0575 mL 0.1149 mL 0.2874 mL
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TPI-287 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPI-287849213-15-6TPI287TPI 287Microtubule/TubulinmicrotubuleBBBbreast cancerInhibitorinhibitorinhibit

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